الفهرس 
High Frequency VentilationOnly 14 pages are availabe for public view
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Abstract
The use of high frequency oscillatory ventilation is common in Neonatal Intensive Care Units as a primary or rescue mode of ventilatory support.
HFOV is powerful tool for elimination of CO2. So, careful monitoring of Co2 levels is important to avoid hypocarbia and hypercarbia. Hypocarbia may cause damage to the central nervous system, such as peri-ventricular leukomalacia, intra-ventricular hemorrhage and cerebral palsy. Severe hypercarbia may cause intracranial hemorrhage and even alteration of conscious level.
Arterial blood gas analysis is the gold standard of monitoring PaO2 (representing the oxygenation status)& PaCO2 (representing the ventilation status) but it has many drawbacks including; it’s expensive, invasive method, leads to blood loss and each sample is only a snapshot view of the sampling moment.
Therefore, alternative method for monitoring of CO2 status is desirable.
CO2 removal during HFOV is directly proportionate to the diffusion coefficient of carbon dioxide which can be calculated as VT2 x ƒ.
Diffusion coefficient of carbon dioxide measurement offers a continuous noninvasive method for monitoring of CO2 status. It can be used to predict change in the arterial CO2 (PaCO2) and help adjust ventilator settings. Also, it reduces the frequency of sampling which can