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العنوان
Effects of albendazole and nitroxynil in rabbits /
المؤلف
El-Boghdady, Eman Abd El-Hamid El-Alfy Mohammed.
هيئة الاعداد
باحث / إيمان عبدالحميد الألفى محمد البغدادى
مشرف / مجدى صلاح مصطفى عامر
مشرف / عزة السيد حسان
مناقش / مجدى صلاح مصطفى عامر
الموضوع
Histopathology.
تاريخ النشر
2020.
عدد الصفحات
online resource (104 pages) :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
البيطري
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة المنصورة - كلية الطب البيطرى - قسم الأدوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Objective: The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedure: group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1st, 7th and 14th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results: The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine and MDA significantly (P ≤0.05) compared with group A.