الفهرس 
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Abstract
This study evaluates the effect of benzene sulfonic acid sodium salt (BSA) as one of the products of the synthetic food coloring sunset yellow degradation on oxidative status in liver and muscles of the experimental rat. Male albino rats (50 ±5 gm) were divided into 6 groups, each group of 15 rats. Group(1): Served as control, group( 2): received turmeric in the diet (3%), group( 3): treated with the (1st dose) of benzene sulfonic acid sodium salt (BSA) ( 19.8 μg /kg), group (4): treated with the (1st dose ) of benzene sulfonic acid sodium salt (BSA) + turmeric , group(5): treated with the (2nd dose) of benzene sulfonic acid sodium salt (BSA) (36.6 μg /kg), group (6): treated with the (2nd dose ) of benzene sulfonic acid sodium salt (BSA) + turmeric.
The results showed a significant reduction in the growth rate percentage (g/week %), food consumption (g/day), hepatosomatic index (HSI) percentage (g %) and significant increase in the spleen weight (g) and spleenosomatic index (SSI) percentage (g %).The results showed significant increase in the activity of the enzymes SOD, CAT and GST within treated groups, and the extent of increase was dose-related. In the other hand the results showed significant decrease in the activity of the enzymes GPx and GR within treated groups, and the extent of decrease was dose-related.
The results showed significant increase in the activity of the enzymes XO and AO within treated groups, and the extent of increase was dose-related. The results showed significant increase in levels of biomarkers MDA and PCO within treated groups, and the extent of increase was dose-related. Benzene sulfonic acid (the degraded derivative
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the sunset-yellow beverages) causes oxidative stress in different body tissues especially liver and skeletal muscle.
The administration of curcumin (a yellow colored polyphenol, is an active principle of the perennial herb Curcuma longa) show improvement in the significant alterations reported in the liver and skeletal muscle resulted from administration of benzene sulfonic acid.
Also from this study, it could be drawn the ability of curcumin to act as therapeutic agent and hepatoprotective against liver and muscles damage as a result of oxidative stress induced by benzene sulfonic acid sodium salt (BSA) and which is related to its antioxidant and free radical scavenger activity.