الفهرس 
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Abstract
Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Hepatocellular carcinoma represents about 90% of primary liver cancers and constitutes a major global health problem. Since HCC usually develops in a damaged liver, the prognosis of HCC depends not only on tumor progression but also on the degree of liver dysfunction. In Egypt, liver cancer forms 23.81% of the total malignancies. HCC constitutes 70.48% of all liver tumors among Egyptians.
Approximately 70%–90% of patients with HCC have an established background of chronic liver disease and cirrhosis, with major risk factors for developing cirrhosis including chronic infection with hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease, and nonalcoholic steatohepatitis (NASH).
Therefore, this study investigated the characteristics of HBV-related HCC as compared to HCC due to HCV in Egyptian patients, presenting to one of the largest centers of HCC in Egypt.
This study was conducted at Tropical Medicine department and HCC unit, Ain Shams University Hospitals. This study enrolled 162 Egyptian patients diagnosed with HCC (140 patients due to HCV infection & 42 patients due to HBV infection) from 2008 till 2019. They were followed up till death or till the end of the study. We included cases with proved diagnosis of HCC according to AASLD practice guidelines, HCC patient with HBsag positive and HCC patient with HCV Ab positive. Patients who refuse to be enrolled in the study or refuse to sign the consent, Patients with incomplete data or with lost follow up and Patients with any other etiology rather than HCV and HBV were excluded from the study.