الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Summary and conclusion
Melasma is a hyperpigmentry complex disorder , which is commonly observed in the daily clinical examinations and associated with many etiological factors.
Melasma treatment with topical agents is both frustrating and challenging and results are often unsatisfactory and topical agents may sometimes cause significant adverse reactions.
Dermoscopy is noninvasive recognition/differential diagnosis of several “general” dermatoses by magnifying both surface structures and subsurface features that are invisible to the unaided eye and reflect the different histopathological background of each condition. (Errichetti E, Stinco G ,2016)
The results of this study demonstrate that treatment of melasma with intradermal microinjection of Glutathione 600 mg with repeated sessions every 2 weeks over a course of three months. All patients showed significant improvement in melasma after dermoscopy evaluation before and after the application.
All three components of melasma ((Vascular, dermal, epidermal) were improved, with the highest rate of improvement in the dermal pigmentation (30%) followed by epidermal pigmentation (20%) and the least improvement degree was in the vascular component;/0p[ts (15%).
The patients’ compliance was better compared with topical applications, due to the faster and profound results.
Although this study was open label, the results are consistent with those from masked studies.