الفهرس 
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Abstract
Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs. They are the major occurrence of chronic wounds, occurring in 70% to 90% of leg ulcer cases. Venous ulcers develop mostly along the medial distal leg and can be painful with negative effects on quality of life. The exact cause of venous ulcers is not certain, but they are thought to arise when venous valves that exist to prevent backflow of blood do not function properly, causing the pressure in veins to increase. When venous hypertension exists, arteries no longer have significantly higher pressure than veins, and blood is not pumped as effectively into or out of the area. Venous hypertension may also stretch veins and allow blood proteins to leak into the extravascular space, isolating extracellular matrix (ECM) molecules and growth factors, preventing them from helping to heal the wound. Most venous ulcers respond to patient education, elevation of the foot, elastic compression, and evaluation. Exercise together with compression stocking increases healing. There is no evidence that antibiotics, whether administered intravenously or by mouth, are useful. Furthermore, conventional therapies such as dressings, surgical debridement, and even skin grafting cannot provide satisfactory healing since these treatments are not able to provide necessary growth factors that can modulate the healing process. Autologous platelet-rich plasma is a simple, affordable, inexpensive method used in treating non-healing ulcers with reportedly good results as it provides growth factors which enhance healing. Since it is an autologous method, it is biocompatible and safe. PRP enhances wound healing by promoting the healing process by multiple growth factors present in it. In our study we assumed that platelet-rich plasma will help in reduction in ulcer parameters up to complete healing in comparison to the conventional compression in the treatment of post-phlebitic venous ulcer. Forty patients were included into the study, and were randomly allocated to two groups, the first group was subjected to PRP application and injection with compression therapy. The other group was subjected to conventional compression therapy alone. The RCVS score was performed, and all ulcer parameters were measured before and 6 weeks after intervention, in addition to pain assessment. After collecting and analyzing the data, the results showed that there was a significant difference between PRP group and compression therapy group regarding post-interventional area of the ulcers (16.9 ± 17.3 cm2 vs 19.2 ± 13.5 cm2). Also, there was a significant difference between PRP group and compression therapy group regarding post-interventional area of the ulcers (1.2 ± 2.9 cm3 vs 3.2 ± 4.9 cm3). There was a moderate direct correlation between pre and post-interventional area in PRP group [r(18)=0.63, p=0.003]. Besides, the decline in pain scores between both groups was statistically significant in favor of PRP group (p<0.0001) at post-interventional 3 and 6 months. Finally, we can report that PRP application and injection added about 30% more in both area and volume reduction after 6 weeks from 1st dose compared to compression therapy alone.