الفهرس 
صفحة العنوانOnly 14 pages are availabe for public view
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Abstract
Objective: Colorectal cancer (CRC) is the most common
type of gastrointestinal tract cancers. It’s the second most
known cancer in women and the third commonest cancer in
men. It causes 800,000 deaths yearly worldwide. The aim
of this work was to assess the expression of miR-576-3p
and miR-613 in.• CRC patients. In addition the
determination of serum levels of NDRG2 and YKL40 to
decide their diagnostic and prognostic significance
according to clinicopathological data.
Methods: Sixty early diagnosed CRC patients and twelve
control subjects with no CRC were involved in this study.
Expressions of miR-576-3p and miR-613 were detected by
real-time PCR while NDRG2 and YKL40 serum levels
were determined by ELISA.
Results: The study results showed that both miRNA-576-
3p and miRNA-613 were down-regulated in CRC patients
with fold change 0.33, 0.36; respectively. A significant
positive correlation was observed between miR-576-3p and
miR-613 (r=0.75, p< 0.01). Serum levels of NDRG2 were
decreased in patients compared to those of control group
however, the difference wasn’t statistically significant. On
the other hand, it was observed that YKL40 serum level