الفهرس 
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Abstract
Introduction : Osteoarthritis (OA) is defined, in general, as an inflammatory process that affects the integrity of the articular cartilage in addition to the underlying bone at the joint edges. The result of its destruction is usually meniscal degeneration, low grade synovitis, weak musculature, malalignment and lax ligaments. Aim of the work : The aim of the present study was to evaluate serum and synovial fluid visfatin as a marker of severity of knee osteoarthritis. Subjects and Methods : The subjects in this study were classified into two groups I: This group included thirty five patients (10 males and 25females) with primary knee osteoarthritis their ages ranged between 50 to70 years. II: This group included twenty apparently healthy individuals (9males and 11females) as a control group Their ages ranged between 40 to 52 years. Conclusion : Serum visfatin was higher in patients group versus control group, Serum and synovial fluid visfatin were positively correlated to the grade of knee OA, Visfatin was higher in SF than serum in OA cases which suggested that visfatin might be included in OA pathophysiology and might have local effects in the joint throughout OA process.