الفهرس 
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Abstract
Stress urinary incontinence (SUI) is a major health problem that have social and economic impacts. So, the present study examined the effect of locally and systemically administrated adipose tissue derived mesenchymal stem cells (ADMSCs) on treatment of SUI in rat animal model.
Forty-eight female Sprague Dawley rats were randomly allocated into two main groups; i) acute (2 weeks) group (24 rats): rats exposed to vaginal dilatation (VD) for 2 weeks then started ADMSCs treatment (either local or systemic) for 4 weeks and ii) i) chronic (4 weeks) group (24 rats): rats exposed to VD for 4 weeks then started ADMSCs treatment (either local or systemic) for 4 weeks. Urodynamic study (abdominal leak point pressure (ALPP), threshold pressure (TP) and bladder capacity (BC) were measured after injury and after treatment. Also, histopathological examination of the periurethral region was done.
The results showed significant reduction in ALPP, TP and BC at 2 weeks and 4 weeks after injury compared to basal value (p < 0.05). Also, the periurethral region showed fibrosis and loss of muscle layers after injury.
Treatment either local or systemic ADMSCs caused significant improvement in urodynamic parameters with regeneration of muscle layers in periurethral region.
This results that VD caused significant functional and morphological damage of urethral sphincters and administration of ADMCs either systemic (via veins) or locally in periurethral region caused significant improvement in morphological and urodynamics dysfunctions of urethral sphincters. Moreover, locally administrated ADMSCs offer more protective effects than the systemically administrated ADMSCs.