الفهرس 
Parkinson’s disease motor and non-motor symptomsOnly 14 pages are availabe for public view
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Abstract
Background: Parkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disease. Gait disorder is so frequent in parkinsonian patients and one of the disabling symptoms for the patients. Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease.
The Aim of this study: To assess predictors of gait disorders in parkinsonian patients as a step to find preventive measures for this disabling problem.
Patients and Methods: This is A Cross sectional observational study for 42 Patients with PD attending our movement disorder outpatient clinic in Ain shams University Hospitals, they were assessed using; Motor Assessment through MDS UPDRS , Gait Assessment through Berg Balance Test , 10 meter walk test , time up & go test and freezing of gait questionnaire, Cognitive Assessment through Addenbrook’s test , Wechsler memory subset , Mini-mental scale examination , Wisconsin Card sorting test, plus non-motor symptoms scale , Beck depression inventory, PDQ-39 and MRI Brain assessed with Fazekas scale and scheltens scale.
Results:
The study ends in statistical significance as regard correlation between duration of illness, levodopa equivalent drug dose and gait assessment scales, correlation between MDS-UPDRS scores and gait scores, correlation between NMSSs and gait score, correlatin between most cognitive scales score and gait scores and finally weak correlation between fazekas score of MRI and gait scores. By multiple regression analysis we found that MDS-UPDRS III on was the independent predictor of TUG during on.
Conclusion:
Gait impairment and FOG in patients with PD occurs more with longer DOI, more advanced disease stage, and with patients receiving larger doses of levodopa. Also it was noticed that more evident NMS associated with gait impairment. Advanced gait score in BB, 10 meter walking test are proportional to more CI. Also CI and dementia more in FOG. MDS-UPDRS III was the independent predictor of TUG during on state.