الفهرس | Only 14 pages are availabe for public view |
Abstract Coronary heart disease (CHD) is a common, chronic and life-threatening illness, and remains the leading cause of morbidity and mortality worldwide. Therefore, the early diagnosis of CHD will lead to rapid and more effective medical intervention, and safe the patients’ life. The aim of this study was to evaluate the potential role of myeloperoxidase (MPO), acid mammalian chitinase (AMCase), chitotriosidase (CHIT1) and N-Acetyl-β-D-Glucosaminidase (NAG) as biomarkers in the early identification of patients with CHD. In addition, the levels of cardiac troponin I (cTnI), CK-MB and myoglobin (Mb) were investigated. Further, the possible use of these biomarkers individually or their combinations to improve the early detection of acute coronary syndrome (ACS) were included. The present study included 100 subjects (63 males and 37 females) with age ranged from 40 to 86 years. Subjects were divided into 4 groups: group I (18 patients) with stable angina (SA), group II (25 patients) with unstable angina (UA) and group III (37 patients) with acute myocardial infarction (AMI). group IV (20 healthy controls) of matched age and sex. The most important findings of the present study were demonstrated as follow: AMI was common in obese males during the period between 6th and 7th decades of life. In addition, the development of a predictive score derived from the combination of baseline levels of cTnI, MPO, CHIT1 and AMCase could provide the required information for early diagnosis of AMI patients. This score could improve outcome and reduce care costs of these patients. The MDA function based on four biomarkers was correctly classified 97% of the AMI patients at a discriminant cut-off score value 2.47 (i.e. less than 2.47 indicated UA and greater than 2.47 indicated AMI) with high degrees of sensitivity (100%) and specificity (93%). The positive predictive and negative predictive values were also high 96% and 100%; respectively. |