الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 124 |  |  |
| | | from | 124 | | |
Abstract
Background: SLE is a highly complex autoimmune disease with obvious heterogeneity between patients, causing any degree from mild to lethal disease, following a regression and remitting course, and with a random natural history. SLE can affect almost always all parts of the body with a high involvement of kidney. Lupus nephritis (LN) affects up to 70% of patients and as many as 19% may develop end stage renal failure. The involvement of different pro- and anti-inflammatory cytokines in the pathogenesis of SLE include transforming growth factor β (TGF-β), Interleukins (IL-6, 10, 17 and 23), B-cell activating factor (BAFF) and interferon (IFN-α and IFN-γ). The imbalance of these cytokines reflects the disproportion among different immune cell, such as T-helper (Th1/Th2) and Th17/Treg, so it best owing extremely to the pathogenesis of SLE. IL-10 function as a dominant B cell stimulant that enhances activation, proliferation and differentiation of B cells which Inhibits Th1 responses and promotes Th2 responses. The aim of the work: Assess serum IL-10 levels in children with SLE. Study the correlation between IL-10 with different clinical manifestations, disease activity, lupus nephritis classes and Study the IL-10 levels in both naïve and previously diagnosed lupus patients Type of study: a case control and a cross- sectional study Materials and Methods: Forty two pSLE patients (2–17 years of age) were recruited from SLE outpatient clinic and from inpatient wards from Mansoura University Children Hospital. Twenty five healthy age-matched volunteer children were recruited from the general outpatient clinic in Mansoura University Children Hospital as controls for serum interleukin-10 assessment. Results: In our study: serum IL-10 levels were considerably elevated in lupus patients more than normal population and have a significant positive correlation with SLE disease activity index (SLEDAI) , serum AntiDNA and ESR there were no significant correlation between serum levels of IL-10 and clinical manifestations and different renal classes. Conclusion: Serum levels of interleukin-10 in cSLE patients are significantly higher than healthy controls and these serum levels correlate well with SLEDAI, serum AntiDNA and ESR Recommendations: Results suggest that interleukin-10 dysregulation may have a role in the pathophysiology of SLE and that supports the possible use of IL-10 as monitoring marker for disease activity.