الفهرس 
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Abstract
The aim of the current study was to investigate the probable immune protective effects of C. Papaya fruit and kiwi fruit respectively, which display immunestimulant, anti-oxidative efficacy against immunedepression and hepatotoxicity, those being the major side effects of Methotrexate (MTX). Rats were divided into four groups: a control group; MTX (20 mg/kg twice weekly) group; Papaya + MTX group (400 mg/kg/day + 20 mg/kg twice weekly) respectively; and Kiwi + MTX group (400 mg/kg/day + 20 mg/kg twice weekly). At the end of the experiment, immunological, biochemical, histopathological and immunohistobiochemical analyses were performed on serum, liver and spleen tissue of rats. We determined Tumor Necrotic Factor ( TNF-α ),Interlukine-10 (IL10), Immunoglobulin M (IgM),Immunoglobulin G (IgG), C-Reactive Protein (CRP), Nitric Oxide (NO), Malondialdehyde (MDA),Reduced Glutathione (GSH), Superoxide Dismutase (SOD), (ALT) and (AST) levels were measured. The histopathological examination revealed a significant decrease in liver and spleen damage caused by MTX in the PEE- and KEE-treated groups (especially in KEE group). On the other hand. We determined increased serum TNFα,Immunoglobulin M (IgM),Immunoglobulin G (IgG), NO,CRP, ALT and AST,also tissue level of MDA values were increased in MTX group, while IL-10, GSH and SOD levels were decreased in the this group. However, In the PEE and KEE groups, the levels serum TNF-α, NO,CRP, ALT and AST as well as the levels of MDA, were decreased and the levels of IL10,Immunoglobulin M (IgM), Immunoglobulin G (IgG ), GSH and SOD were increased. In conclusion, it can be stated that, although Kiwi is more effective in preventing the toxic effects of MTX on the liver tissue, Papaya also has a preventive effect. As a result, we can readily suggest that Papaya and Kiwi can have immunestimulant effect on inflammatory markers and immunoglobulines, hepatoprotective effects by decreasing MDA and NO values as antioxidants against MTX-induced damage in liver of rats.