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العنوان
Histological and Histochemical Study on the Effect of Aflatoxin B1 on the Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Dates /
المؤلف
EL-Sharkawy, Reem Mohamed Ghareb.
هيئة الاعداد
باحث / ريم محمد غريب الشرقاوى
مشرف / مها السيد سليمان
مشرف / غادة حسن الصيفى
مشرف / رانيا إبراهيم ياسين
الموضوع
Histology. Cell Biology.
تاريخ النشر
2020.
عدد الصفحات
160 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
مواد العلوم (المتنوعة)
تاريخ الإجازة
9/11/2020
مكان الإجازة
جامعة المنوفية - كلية العلوم - علم الانسجه
الفهرس
Only 14 pages are availabe for public view

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Abstract

Kidneys are considered the excretory system of the body that filter wastes and excrete disposals. They are highly vascularized, compound tubular glands that function to maintain the composition of body fluids at a constant level.
The parenchyma of the kidney is divided into two major structures: the outer renal cortex and the inner renal medulla. The functional unit of the kidney is the uriniferous tubule. This tubule consists of two parts, each with a different embryological origin, the nephron and the collecting tubule.
Mycotoxins represent the most important category of biologically produced natural toxins relative to human health and economic impact worldwide. They are considered as structurally diverse toxic fungal metabolites.
Aflatoxin B1 (AFB1) is considered to be a major class of mycotoxins that was found to be produced by filamentous fungi especially strain of Aspergillus flavus and Aspergillus parasiticus in feed stuffs. AB1 is found to be hepatotoxic, nephrotoxic, mutagenic, genotoxic, carcinogenic, and immune-suppressive agent in human and animals. Oxidative damage is thought to play a key role in AFB1toxicity.
The fruits of the date palm (phoenix dactylifera L-Areceae) are commonly consumed in many parts of the world. Earlier studies have shown that constituents of dates act as potent antioxidant, anti-tumor as well as anti-inflammatory, provide a suitable alternative therapy in various diseases cure. Antioxidant activity is recognized due to the wide range of phenolic compounds present in dates including p-coumaric, ferulic, sinapic acids, flavonoids and procyanidins.