الفهرس 
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Abstract
Acne is one of the commonest skin disorders. It is multifactorial chronic inflammatory disease of pilosebaceous units. Acne lesions are classified as noninflammatory including open and closed comedones or inflammatory including papules and pustules. Demodex folliculorum and/or Demodex brevis are obligate parasits of the pilosebaceous units. Demodex mites are present in healthy individuals and may have a pathogenic role. The aim of our study is to detect D. folliculorum mites in acne patients and to Study the in vitro effect of neem tree extract on D. folliculorum.
This study was conducted on 500 patients suffering from acne symptoms attending outpatient clinic of the Dermatology Department of Beni-suef University Hospital. Standardized skin surface biopsy and Skin scraping, a noninvasive sampling methods, were taken from patients.
Based on the obtained results of the present study, Patients were distributed as (290) females and (210) males. Their ages were ranged from (13) to (35) with an average age of (18.36 ±3.9) years old and distributed as (244) children (48.4%), (206) adolescent (41%) and (50) post-adolescent (10%). The study participants were mostly rural residents (323), while only about (177) were urban residents.
Regarding acne severity among studied population; the largest percentage of the cases (43.8%) had mild disease (219 out of 500) followed by moderate disese among (37.2%) while (85 cases); (17%) had severe form of the disease and only 10 cases (2%) had very severe form of the disease
The D. folliculorum mites in acne patients were detected only in eight cases among the whole studied population (1.6%). The mites in acne patients were significantly more detected among studied Adolescent cases and among studied cases with severe form of the disease (p-value= 0.027) with statistical significance (p-value== 0.027 and 0.001 respectivaly)
The D. folliculorum mites in acne patients showed no statistical significance with the gender, residence or previous history of trearment (p-value > 0.05).
Neem ethanolic extract effectively killed all adult mite samples within 60 minutes of exposure.