الفهرس 
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Abstract
Non-alcoholic fatty liver disease (NAFLD) is the 2nd most common cause of cirrhosis and liver transplantation worldwide. As the hepatic manifestation of the metabolic syndrome; NAFLD is gaining prevalence worldwide due to the obesity epidemic.
It has been proposed that serum ferritin levels could potentially be used to predict presence and severity of liver fibrosis in patients with NAFLD. However, the evidence associating elevated serum ferritin with severity of liver fibrosis in NAFLD comes, at the best, from the results of multiple logistic regression analyses. The accuracy of serum ferritin levels in diagnosing presence and severity of liver fibrosis has not been formally evaluated.
The aim of our study was to evaluate the usefulness of serum ferritin in patients with NAFLD.
This study is an observational cross-sectional one that was conducted at the Minia university hospital during the period from January to May, 2019. It included 99 patients.
Inclusion criteria:
-Patients with NAFLD with or without hepatic fibrosis.
-Both sexes are included.
-Age more than 18 years.
Exclusion criteria:
1-Age less than 18 years.
2-Patients with medical history, clinical or laboratory evidence of any other liver diseases, such as alcoholic or viral hepatitis, schistosomiasis, autoimmune hepatitis, hereditary liver disease, and those with decompensated liver cirrhosis.
3-Patients with a history of drug usage in the last 2 months.
4-Serum ferritin levels ˃ 1000ng/ml.
All patients were subjected to the following:
1-Complete medical history and clinical examination, including abdominal examination, waist circumference measurement, and body mass index (BMI).Body mass index (BMI) was calculated as weight (kg) divided by the square of height (meters). Waist circumference (WC) was measured while standing at the level of umbilicus.
2- Laboratory investigations.
3-Abdominal ultrasound.
Our study showed the following results:
- Hyper ferritinemia is common among patients with NAFLD
- Serum ferritin was significantly higher in males than females.
- Median serum ferritin levels were elevated in smokers than nonsmokers which was statistically significant.
- No significant correlation between serum level of ferritin and fibrosis stage or hepatic steatosis score.
- No correlation between serum ferritin level and age, body mass index (BMI), the level of liver enzymes, fasting plasma sugar, fasting insulin or serum lipids.