الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma ”HCC” is a leading cause of cancer mortality worldwide. High-mobility group box 1 ”HMGB1” is a nuclear DNA-binding protein which involved in DNA stability, programmed cell death, immune response and inflammatory responses in HCV and HCC. Its over expression was revealed in HCC and different types of human cancers. aim: Investigate the role of HMGB1, as regarding its serum level and SNP rs1045411 polymorphism in predicting HCC risk in chronic HCV patients. Setting: Genetic unit at the Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University. Results: Serum level of HMGB1 showed statistically significant increase in HCC group and cirrhotic one in comparison to control group. It showed high sensitivity (83%) and specificity (97%) in differentiating cirrhotic patients and HCC patients from control individuals. Regarding HMGB1 rs 1045411 SNP polymorphism, the percentage of different alleles among control, cirrhotic and HCC groups was as follows: ”CC’ genotype: 87%, 80%, 80%, ”CT” genotype: 10%, 20%, 17% and ”TT” genotype: 3%, Zero% and 3%. This showed no statistically significant difference between the genotype distribution among studied groups, nor between the studied groups and the general population. Conclusion: serum level of HMGB1 is raised in cirrhosis and HCC than normal liver, which could be used as a predictive marker with high sensitivity and specificity value. Regarding HMGB1 SNP rs1045411, the wild ”C” allele has higher frequency among HCC patients than the mutant ”T” one.