الفهرس 
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Abstract
The dissipation and residual levels of abamectin, spinosad, and acetamipride were determined by HPLC-DAD moreover, penconazole, diniconazole and fipronil determined by using GC-ECD in tomato fruit under field conditions using QuEChERS methodology.The dissipation half-life time ofabamectin, spinosad, acetamipride, diniconazole, penconazole and fipronil residues in tomato fruits were 3.91, 0.36, 1.19, 0.71, 4.19 and 1.78 days, respectively. According to the maximum residue limits (MRL). The pre-harvest interval (PHI) of abamectin, spinosad, acetamipride, diniconazole, penconazole, and fipronil were 10, 1, 1, 10,5 and 21daysafter the application, respectively. This recommended that the use of tomato fruits treated with these pesticides were safe for consumptionafter these intervals. This study might be useful to prevent the health problems might be occurred due to consumption the polluted tomato fruits. Also, studied the acute and sub-acute toxicity of acetamiprid and diniconazole on some biochemical parameters in blood and their histopatholgical effect on liver, kidney, and brain tissue of albino rats and found that acetamiprid and diniconazole may induce alterations in hematological and biochemical parameters. They could be hepatotoxic, nephrotoxic, and neurotoxic. The adverse effects of diniconazole may be more than acetamiprid on plasma, liver, kidney, and brain.