الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 151 |  |  |
| | | from | 151 | | |
Abstract
SUMMARY
Ovarian cancer is one of the three most common malignant tumors in the female reproductive system. Early diagnosis is difficult and the onset of the disease is much unpredictable. The most common type of ovarian cancer is epithelial cell tumors. Epithelial ovarian cancer constitutes 90% of ovarian malignancies and 25% of women’s genital malignancies. It is usually fatal due to late diagnosis.
Since the symptoms of this disease are not usually easy to diagnose and mimic other complications, the prompt diagnosis becomes difficult. In fact, more than 60% of patients with ovarian cancer are diagnosed when the cancer has progressed to a great extent so that their prognosis is poor.
RMI score is developed to measure the risk of ovarian cancer. CA-125, ultrasound features and the menopausal status are the main fundamentals of RMI. The RMI has shown remarkable ability to distinguish epithelial ovarian carcinoma (EOC) from benign ovarian tumors.
Adnexal tumors represent a wide variety of diseases that may affect the ovaries and/or fallopian tubes. Tumors of the adjacent structures, such as uterine fibroids, can mimic adnexal tumors. Ovarian tumors can be functional, benign, or malignant. Ovarian malignancies can be primary or secondary, with primary tumors originating from epithelial cells, sex cords, or germinal cells. The heterogeneous nature of adnexal masses is one of the causes of preoperative difficulties in these tumors.
The aim of the study is to assess therisk of ovarian malignancy in premenopausal women with ovarian mass and low CA125.
This is an observational Multi-centric study done in Beni-Suef University, Egypt with co-participance with king Fahad and King Saud Medical Cities, Saudi Arabia, the study was conducted according to the guidelines for good clinical practice for research and declaration of Helsinki. All premenopausal women with complex adnexal masses participated in the study.It included (200) patients who had a diagnosis of complex adnexal mass clinically or by ultrasound scanning.
The main results of the study revealed that:
• Mean age of the studied cases was 37.76±11.68 years with range of (17-52) years.4% of cases had ages ≤20, 41% had ages (21-39)years, 46.5% had ages 40-49, 8.5% had ages between 50-52. Median parity was 2 with a range of (0-4).
• Mild risk of malignancy was in 39% of cases, moderate risk was in 45.5% while severe risk was in 15.5% of cases.
• There is high significant relation between incidence and risk of malignancy by RMI score.
• 27% of cases had malignant tumors while 73% of cases had benign tumors
• There is high significant relation between incidence of malignancy and risk of malignancy by RMI score, based on the results We recommend for further studies on large geographical scale and on larger sample size to emphasize our conclusion.