الفهرس 
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Abstract
Over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) are among the most sold pharmaceutical drugs worldwide. These molecules have excellent reputations within the general population and are widely used for self-medication and prophylaxis, and are also present in the environment (Verlicchi et al., 2012). Dissolution rate and therapeutic activity of a drug depend on its physical state and, particularly, on its degree of crystallinity. Disordered amorphous materials dissolves faster and has a greater solubility, As a consequence, the amorphous form of a drug often shows an improved therapeutic activity. However, the amorphous state is a non-equilibrium state and, consequently, it is unstable (Correia et al., 2001).
There is often abuse or excessive consumption, including in population subgroups to prevent pain and treat injuries. The risks associated with the misuse of mild analgesics, such as hepatotoxicity, cardiovascular side effects or inducing asthma are well known. Recent findings indicate that paracetamol and NSAIDs have endocrine disruptive potential during fetal life. Indeed, several independent epidemiological studies indicate the existence of a significant association between the intake of NSAIDs drugs during pregnancy, and an increased risk of cryptorchidism in newborn boys. Mild analgesics were also found to display anti-androgenic effects in the rat fetal testis in vitro (Albert et al., 2013). NSAIDs play an important role in postoperative pain management. Countless studies have demonstrated their effectiveness following surgeries of all types, leading to their inclusion in many multi-modal pain control regimens (Sivaganesan et al., 2017).
Indomethacin, a non-steroidal anti-inflammatory drug was synthesized in 1963 for the treatment of rheumatoid arthritis It is an indolemathylate derivative that has antiinflammatory, analgesic and anti-pyretic activities (Ilahi et at, 2006; Polat et al., 2010). Indomethacin exert its effect by potently inhibiting prostaglandin synthesis. It is used in patients that are refractory to other drugs. But despite its potency, indomethacin is not continually used as an analgesic or antiphyretic because its toxic effects have become apparent with its wider use (Adedapo & Aiyelotan, 2001).
The use of indomethacin in preterm infants remains controversial, as indomethacin reduces the incidence of severe intraventricular hemorrhage and subsequent symptomatic patent ductus arteriosu. However, indomethacin has not been shown to prevent bronchopulmonary dysplasia, despite a strong association between patent ductus arteriosus and the development of bronchopulmonary dysplasia. The available data from randomized trials are consistent with the hypothesis that prophylactic indomethacin may adversely affect respiratory system (Jensen et al., 2017).
The adverse effects of indomethacin include gastric and peptic ulceration may involve haemorrhage and acute perforation of colonic diverticuli, nausea, headache, dizziness, depression and psychosis. Infact acute renal failure associated with the concomittant administration of indomethacin and triamterene has been reported by (Brooks et al., 1999). Indomethacin has an intraperitoneal lethal dose of 13mg/kg in rats, this drug has been used widely as a rodenticide in the local community and the drug