الفهرس 
Review of Literature .Only 14 pages are availabe for public view
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Abstract
Summary
Autism spectrum disorder (ASD) is a common complex neurodevelopmental disorder characterized by persistent deficits in social communication and interaction, restricted, repetition of behavior and interests.
Furthermore, it was stated that children with ASD have high incidence of abnormal encephalography (EEG) findings even with no seizures, together with affected intelligent quotient and low daily living skills and social skills.
Interestingly it was mentioned that the detection of epileptiform activities in children with ASD even if there is no seizure raises questions regarding the effect of pre and perinatal insults as risk factors for ASD with significant EEG abnormalities.
For all previous reasons we find it of a great magnitude and a wide field of interest, so this study was established and aiming for finding a better plan of prevention of more cases of ASD and confirming that early proper investigations, diagnosis and treatment of the child improves the prognosis and decreases the burden both on the patient and the family.
Cross sectional study was designed that included 50 children aged from 3 years to 13 years old who were diagnosed as ASD cases according to DSM V; they were selected according to the inclusion criteria from ASD cases regularly attending the Child Psychiatry Clinic of Faculty of Postgraduate Childhood Studies, Ain Shams University during the period from April 2015 till December 2017. Any autistic child who had double syndrome, inborn errors of metabolism, or major cardiac problems were excluded from the study.
All the studied patients were subjected to examination and investigations as follows:
Physical examination
Vineland Adaptive Behavior Scales
Childhood Autism Rating Scale CARS
Electroencephalography study for detection of EEG abnormalities.
Regarding the incidence of ASD, there was a higher percentage of male than female, the ratio was 2.5: 1 respectively
There is relation between of both prenatal and postnatal insults and components of Vineland scale among the patient group with autism there was a statistically significant difference in daily living skills, however there was no statistically significant difference in other components of Vineland scale
There is relation between sleep/awake during EEG changes of the patient group with autism, there was a statistically significant difference regarding right and left background activity with P value 0.043*, 0.016* respectively
There is relation between prenatal insults and EEG changes of the patient group with autism, there was a statistically significant difference regarding the Left focal epileptiform activity which presented by P value 0.034*
There is a statistically significant difference regarding the right and left background asymmetry presented by P value 0.010*, 0.037* respectively when the relation between postnatal insults and EEG changes of the patient group with autism were studied
There is a statistically significant right and left frontal slowing in children with ASD who were exposed to maternal hypertension during gestation and in children presented by delayed first breath. Also right and left frontal slowing were found in autistic patients who have history of neonatal sepsis presented by P value 0.007** and right central slowing presented by P value 0.001**.
There was a statistically significant difference showing P value 0.050* regarding the right focal epileptiform activity in those autistic patients who exposed to maternal UTI during pregnancy.
Again right and left background asymmetry with statistically significant difference and P value 0.043* and 0.016* respectively in patient group suffered from fetal distress.
Left central slowing was differently statistically significant in both of those children with gestational age less 36 weeks and those with Birth weight less than 2500 gram.
There is a statistically significant difference regarding the Rt Background asymmetry in patient group with autism who had history of NICU admission with P value 0.015*
There is a statistically significant difference regarding the right frontal slowing and left focal epileptiform activity during studying twin in the patient group.
Finally, the relation between CARS final result which represent severeity of ASD and EEG changes of the patient group with autism, there is a statistically significant difference regarding the Right focal epileptiform activity with P value 0.050
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