الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
One of the most common side effects of chemotherapeutic agents is hepatotoxicity. Here two models of chemotherapeutic induced hepatotoxicity in female mice were studied: cisplatin- and methotrexate-induced hepatotoxicity. Hepatotoxicity of most chemotherapeutic agents is attributed to oxidative stress, inflammation, which finally lead to apoptosis of hepatocytes. Most recent studies tend to use anti-oxidants to protect hepatocytes from injury. According to that, protocatechuic acid and vinpocetine in both models were used due to their anti-oxidant, anti-inflammatory, and anti-apoptotic activities. bino mice were used and divided into 12 groups control group for each model, cis group, cis+p100, cis+p150, cis+v10, cis+v30, methogroup, metho+p100, metho+p150, metho+v10, metho+v30. Twenty four after the end day mice were scarified. Blood samples were withdrawn for serum measurement. Liver was dissected for homogenate preparation, histopathological analysis, and immunohistochemical analysis. Results: Protocatechuic acid and vinpocetine administration normalized tissue level of liver markers (serum aminotransferases, ALP, GGT, albumin, and bilirubin), the antioxidant markers (GSH, MDA, and SOD), inflammatory markers (IL-6, TNF-α, NF-kβ, and iNOS) and apoptotic markers (Annexin-V, caspase3, and Bax) in the liver caused by cisplatin and methotrexate. Conclusion: Presented results suggest that protocatechuic acid and vinpocetine in a dose-dependent manner can protect hepatocytes from cisplatin and methotrexate induced liver injury. Therefore, they may represent promising protective agents against chemotherapy induced liver injury.