الفهرس 
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Abstract
The success of autogenous tooth transplantation depends on the pulp reaction. Auto-transplantation maintains the PDL with the possibility of pulp regeneration, revascularization, and re-innervation. The aim of this study was to evaluate pulp and periodontal regeneration in autogenously transplanted immature permanent teeth treated with apexification and regenerative endodontics. The aim was also to find out if revascularization and ingrowth of new pulp tissue was influenced by the removal of the original pulp tissue before auto-transplantation using regenerative treatment.
Study design: One hundred single-rooted maxillary and mandibular incisor teeth from ten healthy Mongrel dogs, 5 months of age, were randomly divided into 6 experimental groups of 20 teeth each. group I: Auto-transplantation without regenerative endodontic procedures. group II: Auto-transplantation with regenerative endodontic procedures after removal of their pulps coronally one-week past transplantation. group III: Auto-transplantation after removing pulp tissue from the apical side (no access preparation) and treated with regenerative endodontic procedure one-week past transplantation. group IV: Auto-transplantation with apexification procedures. group V: Regenerative endodontic in place. group VI: apexification in place. The animals were sacrificed, histologic sections were prepared and three groups were evaluated for presence or absence of apical closure and ankylosis.
Results: histological apical closure of the specimens recorded in all groups in group V; (70%) and group I; (60%) followed by group VI;(60%) then group IV; (35%) and group III; (30%) while group II recorded the lowest histologic apical closure; (20%). Lost specimens were recorded predominantly in group IV; 8 (40%) followed by minority of specimens’ loss in group I; 2 (10%) with no loss in other Groups. Radiographical apical closure was observed in majority of specimens in group V; (80%) group VI; (80%) followed by group I; (75%) then group IV; (55%) and group III; (30%) while group II recorded the lowest radiographic apical closure; (20%).Ankylosis and periapical granulation tissue was observed in majority of specimens in group I; (75%) followed by group II; (60%) then group III; (55%) while group IV recorded the lowest ankylosis specimens; (50%) no record for ankylosis in group V and group VI.
Within the limitations of this study we can conclude that:
1. Apical closure of the immature permanent teeth with open apex after auto-transplantation was possible, and it’s better done without further endodontic producers neither regenerative endodontic procedures nor apexification.
2. Endodontic interference shouldn’t be done until complete healing of the periodontal ligament. This has great clinical significance as early endodontic treatment decreases the chance of original pulp healing and revascularization interferes with healing of periodontal ligament leading to some tooth mobility.
3. Removal of the original pulp apically during auto-transplantation has no effect on pulp regeneration and apical closure specially if the tooth was undergoing endodontic treatment.