الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Acute leukemia is a cancer of the early blood-forming cells that affects
the blood and bone marrow and can be divided in two main classes; acute
myeloid leukemia (AML) and acute lymphocytic Leukemia (ALL). The
accumulation of these malignant clones dominates on the normal bone marrow
activity and leads to marrow failure. In AML, the survival and proliferation of
hematopoietic progenitor cells are enhanced by both deregulation of many
signaling pathways and abnormalities occur in the transcription factors
functions Angiogenesis is one of the factors is involved in the process of cancer
progression and metastasis. Angiogenesis is a sequence of different processes
that start with the diltation in pre-existing vessels then proliferation of
endothelial cells, development of new blood vessels and recruitment of the
perivascular cells (PCs). Therefore, angiogenesis is a key factor in tumor
progression and metastasis. Vascular endothelial growth factor (VEGF) is one
of the growth factors well known for controlling the angiogenesis process.
Vascular endothelial growth factors (VEGF) are a group of
angiogenesis-promoting proteins has a role in primary tumor growth, invasion
and metastasis associated with many cancer types like breast, lung, renal and
prostate cancers as well as leukemia .VEGF is highly polymorphic gene, and
its promoter, 5’- and the 3’-untranslated region (UTR) has a variety of Single
nucleotide polymorphisms (SNPs) which found to be associated with variations
in VEGF protein production. VEGF 699947 SNP is found in Peripheral Blood
Mononuclear Cells of Iranian, Australian, Caucasian and African patients with
acute myeloid leukemia.