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العنوان
The effect of adding pregabalin to the analgesic effect of intravenous morphine in patients with multiple fracture ribs /
المؤلف
Mahfouz, Mena Medhat.
هيئة الاعداد
باحث / مينا مدحت محفوظ اسحق
مشرف / محمود عبد العزيز على
مناقش / اسامة هلال احمد
مناقش / محمد فتحى مصطفى
الموضوع
Morphine.
تاريخ النشر
2020.
عدد الصفحات
55 p. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
التخدير و علاج الألم
الناشر
تاريخ الإجازة
30/12/2020
مكان الإجازة
جامعة أسيوط - كلية الطب - Anesthesia, ICU and pain managemen
الفهرس
Only 14 pages are availabe for public view

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Abstract

Rib fractures are a common condition after trauma, with up to 10% in trauma overall, and up to 39% in blunt chest trauma. Traumatic fractures are associated with significant morbidity and mortality, and mortality rates of 10-16% have been reported. An estimated one-third of patients with rib fractures develop secondary pulmonary complications with a mortality rate of 65%. Pain is a factor contributing to the outcome due to insufficient pain-induced respiratory efforts leading to atelectasis, difficulties removing secretions and an increased risk of pneumonia. As a result, adequate analgesia is a primary intervention in the management of patients with rib fractures There are a variety of ways to manage a patient’s pain . The main drawback is the possibility of side effects resulting from the use of one type of analgesic, especially opioid analgesics, and patients need more monitoring and intensive care by doctors and nurses There are a variety of ways to reduce this, and we chose to use two different types of medication, namely, intravenous morphine and oral pregabalin to reduce the harmful effects of each of them In this study, 60 patients who agreed with the requirements of the study were selected. They were divided into two groups, each group consisting of 30 patients group A: 30 patients will receive intravenous morphine at a dose of 0.01 to 0.02 mg per kg for five days over the course of twenty-four hoursgroup B: 30 patients will receive intravenous morphine at a dose of 0.01 to 0.02 mg per kg for five days over the course of twenty-four hours and will be given pregabalin orally in a tablet dose of 75 mg twice a day for five days Evaluation criteria included; Demographic data (age, sex, height, weight, body mass, and number of broken ribs), clinical data (pain scale, heart rate, systolic and diastolic arterial blood pressure, sedation scale) and number of days the patient spends in the intensive care unit, and the need to mechanical ventilation. As for the results we found that , intravenous morphine can relieve pain and sedate patients with multiple rib fractures without any added effect from the use of oral pregabalin The need for mechanical ventilation and the requirements for rescue analgesia did not differ significantly between the two groups There were no statistically significant differences in the hemodynamic and respiratory variables such as heart rate, systolic and diastolic arterial blood pressure and blood oxygen level between analgesia using only intravenous morphine or intravenous morphine and oral pregabalin.