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العنوان
Synthesis, characterization and Biological Applications of Some Metal Complexes Derived from Hydrazones /
المؤلف
Khalifa, Rana Mohamed Motawea Ahmed.
هيئة الاعداد
باحث / Rana Mohamed Motawea Ahmed Khalifa
مشرف / Arafa A. Belal
مشرف / Nasser M. Hosny
مشرف / Mohamed H. Abd El-Rahman
مناقش / Nagwa A. Nawar
مناقش / Mohamed M. Hassanian
تاريخ النشر
2020.
عدد الصفحات
167 p. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Multidisciplinary تعددية التخصصات
تاريخ الإجازة
18/11/2020
مكان الإجازة
جامعة بورسعيد - كلية العلوم ببورسعيد - Chemistry Department.
الفهرس
Only 14 pages are availabe for public view

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Abstract

Twelve metal complexes of hydrazone derivatives (2-(2-aminobenzoyl)-N-ethylhydrazine-1-carbothioamide, N-benzyl-4,5-dihydro-3-methyl-5-oxo-1H-pyrazole-4-carbothioamide and N’1,N’3-di-isonicotinoylmalono- hydrazide) with Co(II), Ni(II), Cu(II) and Zn(II) acetates have been synthesized. The compounds have been characterized by elemental, spectral (IR, UV-Vis, 1H&13C NMR, MS and ESR), magnetic and thermal measurements. The measured optical band gap was determined. Theoretical studies ( molecular modeling) were applied on the ligands and their Co(II), Ni(II), Cu(II) and Zn(II) complexes . Biological Activity (in vitro cytotoxic activity against the examined Hela and WISH cell line) and molecular docking were studied for the ligands and their metal complexes.