الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
As the cystoscopy only can evaluate the bladder mucosa, here the role of MRI seems to be a basic way of knowing the multiplicity of the lesions, extra vesical tumor extension, lymph nodes involvement and distant tumor spread. In current study, we aimed to evaluate the role of multiparametric-MRI with its main three components (T2WI, Diffusion weighted image & Dynamic contrast enhanced MRI) as a comprehensive technique for determining local staging and histopathological grade of urinary bladder cancer, and characterizing regional lymph nodes. We examined 54 patients with bladder cancer by multiparametric MRI. The overall diagnostic performance of mp - MRI was more accurate and correctly diagnosed the local T stage in 51/54 patients (94.5%) if compared to the diagnostic performance of T2WI (72.3%), diffusion weighted MRI (92.6%) and dynamic contrast enhanced (87.1%) each single sequences alone. Newer advances like dynamic contrast enhanced MRI and diffusion weighted MRI can add onto more information in evaluation of bladder cancer. They are comparable in staging and grading of bladder cancer as well as their precious role in follow up and thus combination of such functional sequences should be advocated whenever differentiation has to be made out between superficial and muscle invasive disease during preoperative workup and post-operative follow up. The time-signal intensity curve of the DCE-MRI can predict the grade of malignant urinary bladder tumor. Type I (Ascending) & II (Plateau) curves are identified in low grade tumors while type III (Descending) curve is identified in high grade tumors.Also, in the dynamic contrast enhanced MRI, there is a statistically significant correlation between the histopathologic tumor grade and relative enhancement