الفهرس 
Introduction and rationaleOnly 14 pages are availabe for public view
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Abstract
Vitiligo is a common skin disease with unknown etiology. It is multifactorial disorder that involves several theories about its pathogenesis.
The biological functions of survivin, other than its antiapoptotic effect, are not well understood in human. However, many studies have defined its role in regulating functions of several normal adult cells suggesting that survivin disruption could have adverse consequences. Interestingly, survivin was not previously evaluated, studied, described, or investigated in the fibrosis progression of the cutaneous tissues but its upregulation has already been described in certain liver diseases and during hepatic stellate cells activation. This proves to large extent the potential role of survivin in fibrogenesis process, most likely through regulation of apoptosis.