الفهرس 
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Abstract
The main objective of the current study is to assess the relation of polymorphisms of AGTR1 with hypertension, and perform a meta-analysis of association of the rs5186 SNP and hypertension to both understand the relationship between genetic variant and hypertension across multiple populations. The renin-angiotensin system (RAS) plays a fundamental role in blood pressure maintenance and is implicated as a likely etiologic factor in the development of hypertension, gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association with essential hypertension in a Northern Indian population. AGTR1 encodes the type 1 receptor, which mediates the main cardiovascular impact of angiotensin II including vasoconstriction, stimulation of Na+ reabsorption and aldosterone secretion. This gene may play a role in the generation of reperfusion arrhythmias following rebuilding of blood flow to the ischemic or infarcted myocardium.
The distribution of genotypes in the patients (with heart & kidney diseases), and control groups conformity with the Hardy-Weinberg balance, showed that heterozygous genotypic type (CC) is more common in patients with kidney and heart diseases than (AC), while in controls, the most frequent genotype was AA (Table 1). There was a significant correlation found in the AT1R genotypes (AC+CC) with basic hypertension (x2 =64.765, p = 0.000) compared with controls. Also, a significant association of hypertension (AT1R occurrence) was found in alleles (A+C) (x2 =22.947, p = 0.000) compared with control.
Our work revealed that A allele and AA genotype of AT1R A1166C gene polymorphism are related with a protective impact against basic hypertension, while C allele and AC genotype of AT1R A1166C are associated with elevated risk of basic hypertension in kidney and heart diseases.
Keywords: receptors, angiotensin II, genetics, polymorphism, cardiovascular diseases, hypertension.