الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic colitis is defined as an inflammation of the mucosal lining of the colon and it can be associated with abdominal pain, diarrhea, fever, tenesmus and blood in stool. Colitis is a major problem worldwide. The aim of this work was to study the causes, clinical picture, laboratory investigations, gastrointestinal endoscopic findings and response to treatment in children with chronic colitis attending the Gastroenterology Clinic in AUCH in one year period from June 2018 to May 2019.
It was a prospective cross sectional study. The study included all children with symptoms of chronic colitis and needed endoscopic examination for reaching final diagnosis. They were interviewed for full history, clinical examination, investigations, endoscopy and response to treatment.
By the end of the study, 110 patients were included. The majority of the cases were diagnosed as allergic eosinophilic colitis (51%) followed by IBD (38.1 %) then infectious colitis (6.3%), to less extent, colitis associated with immunodeficiency, Behcet’s colitis and microscopic colitis. The final diagnosis was reached after doing lower GI endoscopy and after histopathological assessment of the biopsies.
Statistical analysis of data obtained from the present study showed the following results:
1- Abdominal pain and bloating were the most common associating symptoms (82.7%, 71.8% respectively).
2- Majority of cases of allergic esoinophilic colitis were in the younger age group while IBD cases were in the elder age group.
3- Nocturnal diarrhea, tenesmus, weight loss, pallor, arthritis, severe abdominal pain and nocturnal abdominal pain were significantly predominant in the IBD group when matched with other groups.
4- Anemia and thrombocytosis were significantly more prevalent in the IBD group when matched with other groups.
5- Fever, high ESR and high CRP were significantly more common in the infectious colitis group.
6- Atopy and eosinophilia were significantly more common in the allergic eosinophilic colitis group.
7- Allergic eosinophilic colitis presents as left sided colitis while IBD presents as pancolitis. Ileitis was significantly more common in Crohn’s patients.
8- FC was significantly positively correlated to CRP, ESR, endoscopic severity sub score and severity of abdominal pain.
9- FC above 744 microgram/gram was highly sensitive and highly specific for IBD.
10- Endoscopic severity score was significantly positively correlated to CRP, ESR and WBCs.
11- Clinical activity score was significantly correlated to ESR, CRP, endoscopic severity score and FC in IBD patients.
12- Eosinophil count in the tissue biopsies were significantly correlated to ESR, CRP and WBCs in allergic eosinophilic colitis.
13- Interleukin 10 level and interleukin 10 receptor mutations were normal in the two patients diagnosed as infantile onset IBD.
14- All patients with infectious colitis improved after treatment while 73.2% of patients with allergic eosinophilic colitis improved after treatment. 73.8% of IBD patients improved after conventional treatment.