الفهرس 
Endomeettrriiall Carrcciinoma
Miscarriages and AbortionOnly 14 pages are availabe for public view
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Abstract
S SU UM MM MA AR RY Y
In this study, endometrial carcinoma has been chosen because of its high incidence rate and the poor 5-year survival rate for patients with advanced/recurrent measurable disease who unfortunately have limited treatment options aiming to participate in developing the prognostic aspects of endometrial carcinoma through spotting the light on immune check point proteins (PD-L1 and CTLA-4) together with Tumor Infiltrating Lymphocytes (TILs) and help finding new targets for immunotherapy especially for advanced cases.
The present study was carried out on 50 cases diagnosed as endometrial carcinoma received in Department of Pathology, Faculty of Medicine, Tanta University and from some private pathology laboratories. Specimens were collected as paraffin embedded tissue blocks of total hysterectomy and a BSO alone or total hysterectomy and BSO and pelvic and/or para-aortic lymph node dissection. Histopathological examination was performed on H&E stained tissue sections to determine the histological type and grade of each tumor. All cases of this study were stained for PD-L1, CTLA-4, CD4 and CD8.
The aim of current study was to conduct a systematic assessment of the expression of immune checkpoint molecules (PDL-1 and CTLA-4) in endometrial carcinoma across different histopatholgical types in relation to tumor infiltrating lymphocytes (TILs) and other clinicopathological parameters.
In this study, all cases were females with age ranged from 34 to 71 years (mean age 56 years). The studied cases were divided into 2 groups (low and high expression) based on the median CD8+ and the median CD4+ cell