الفهرس 
Definition of high fat dietOnly 14 pages are availabe for public view
 |  | from | 153 |  |  |
| | | from | 153 | | |
Abstract
HFD is a significant risk factor for many disease states, including cardiovascular and metabolic disorders.
Weight gain and obesity may develop after a prolonged period of a small energy imbalance but it is also possible that it may be a result of periodic bouts of large, positive energy balance, achieved by temporary increases in intake or decreases in physical activity.
Fat substitutes are substances that look, feel and/or taste like fat. Some have calories, while others are low in calories or are calorie-free. The three main categories of fat substitutes are carbohydrate, protein and fat- based. Common carbohydrate- based fat substitutes include cellulose, protein-based fat substitutes, such as egg white and whey protein while fat-based fat substitutes as palm oil, with more fatty acids than triglycerides.
This study aimed to investigate the effect of some fat substitutes on the biological and biochemical parameters of rats fed on high fat diet .
Thirty six adult female albino rats, weighting (115±5g), from Medical Insects Research Institute, Dokki, Giza. were used in this study.
group 1: Normal rats fed on basal diet as a negative control group (6 rats).
group 2: Rats fed on high fat diet as positive control group (6 rats).
group 3: Rats fed on high fat diet with 10% palm oil as a fat source of fat substitutes (6 rats).
group 4: Rats fed on high fat diet with 10% whey protein as a protein source of fat substitutes (6 rats).
group 5: Rats fed on high fat diet with 10% dextrin as a carbohydrate source of fat substitutes (6 rats).
group 6: Rats fed on high fat diet with 10% cellulose as a carbohydrate source of fat substitutes (6 rats).
At the end of experimental (28 days), the blood samples were collected after 12 hours fasting and serum was separated for determination of lipid profile (total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c), atherogenic index (the ratio between LDL-c+VLDL-c/HDL-C), liver function (AST, ALT), kidney functions (urea, and uric acid), glucose and minerals (Ca, P, Mg and Zn). At the same time, the organs: liver and heart were removed, washed in saline solution, dried by filter paper, weighted, and kidney, liver and pancrease were stored frozen in formalin solution 10% for histopathololgical examinations.
The data were statistically analyzed using a computerized costate program by one way ANOVA. The results are presented as mean± SD. Difference between treatments at (p<0.05) were considered significant.