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Abstract Malachite green is a synthetic cationic dye that has many uses including textile dyeing industry (dyeing cotton, wool and paper), biocide in aquaculture and as a medical disinfectant against fish microbial pathogens; also may be used as food additive. Malachite green showing several toxicological symptoms; together with carcinogenicity, and mutagenicity to mammalian cells by formation of free radicals, also acts as a liver tumor promoter. Green tea is considered to be anti-inflammatory, anti-oxidative, anti-mutagenic, and anti-carcinogenic, and can prevent cardiac disorders. Green tea also seems to protect the liver from the damaging effects of toxic substances. Green tea extract is a water soluble polyphenolic compound act as antioxidant by scavenging radicals. The aim of this study was to evaluate the ameliorative potential of green tea extract against malachite green dye-induced oxidative stress and biochemical alterations in male rats. In this study thirty-six healthy male rats were divided randomly into 6 groups (6 animals each) treated orally by gavages with malachite green and / or green tea extract approximately at the same time each morning, 3 days per week for 6 weeks as follow. |