الفهرس 
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Abstract
Dissertation Abstract Introduction: The quality of recovery is an essential factor that must be assessed in all patients undergoing surgery under general anesthesia. In the past, the only option for reversal of the effect of NMBDs was cholinesterase inhibitors, which cannot be used in profound neuromuscular blockade. Also, these drugs are has a variety of cholinergic side effects which need administration of an anticholinergic drug , with the adverse effects related to it. The Aim of this study: To compare reversal efficacy of sugammadex and neostigmine in pediatric patients undergoing cardiac catheterization by measuring the time from the administration of sugammadex or neostigmine (T2 reappearance) to recovery of the TOF ratio to 90% after rocuronium-induced neuromuscular block. Materials and methods: This prospective, randomized, controlled and double-blind study was carried out in Mansoura University Children Hospital over one year after approval by the local ethical and scientific committee (IRB-MFM) with reference number (MS.19.08.759, septembre2019) and obtaining written informed consents from legal guardians of each patient. This study was carried out on 50 patients of either sex with age less than two years. These patients were admitted to Mansoura University Children Hospital for cardiac catheterization. Results: sugammadex can be rapid and effective alternative for reversal of rocuronium induced neuro-muscular blockade in pediatric patients less than two years. sugammadex may provide stable cardiac conditions with minimal effects on hemodynamics in pediatrics with congenital heart disease but further studies are required to assure the safety of the drug in this category of patients. The time from administration of reversal (T2 Reappearance) to TOF 90% was significantly less in Sugammadex group than Neostigmine group. There was no significant difference between the two groups in the incidence of post reversal events (eg; hypotension, bleeding, vomiting, anaphylaxis). There was no significant difference between two groups in terms of heart rate just before reversal, one minute and 15 minutes after the medication. There were significant increases in heart rate at the other time points after reversal in Neostigmine group when compared to Sugammadex group.