الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Teeth extraction is considered as one of the most performed procedures in dentistry. Extraction of teeth is followed by bone resorption of the ridge at socket site, which leads to loss of length and width, which impairs future implant placement. There are many materials used to prevent this problem as socket preservation materials, such as bisphosphonates, which are anti-resorption drugs. Alendronate is a bisphosphonate drug which is usually used as a systemic medication in bone disorder diseases to reduce bone resorption. Purpose: This study was designed to evaluate the effect of alendronate gel on alveolar bone when applied topically in combination with collagen cone packed inside the socket immediately after maxillary premolars extraction. Materials and Methods: Sixty healthy patients with age between 18 and 40 years seeking for simple extraction of maxillary premolars were included in the study. Patients were selected from the Outpatient Clinic of the Oral and Maxillofacial Surgery. Department, Faculty of Dentistry, Mansoura University. The patients were divided into three equal groups. After extraction of maxillary premolars in group I, no material was packed in the socket, while in group II, the extraction socket was packed with collagen cone, and in group III, the socket was packed with collagen cone soaked with 1% alendronate gel. After one week of extraction, patients were evaluated clinically for pain, soft tissue healing and socket complications. Patients were evaluated radiographically by cone beam computed tomography (CBCT) immediately after extraction and four months later to determine the amount of bone loss prevented in both height and width. Results: Clinical evaluation revealed that topical alendronate was irritant and delayed the wound healing, which finally healed normally. Radiographic evaluation showed a high statistical significant difference of alendronate gel in preventing bone resorption, but with no statistical significance in bone density after 4 months of extraction. Collagen had no statistical significance in both bone density and socket preservation, except in bucco-palatal width. Conclusion: Collagen cone soaked with 1% alendronate gel when packed in the socket immediately after extraction of teeth prevents post-extraction alveolar ridge resorption with negative effect on bone density.