الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Treatment of schistosomiasis has two ways; prevent or reduce tissue damage in infected individuals .The use of drugs that are safe and effective will remain the main tool in reducing this damage until a successful vaccine is produced.
Although praziquantel (PZQ), the drug of choice for treatment of schistosomias till now, is an effective and safe as ani-schistosomal drug but there are increasing problems of the resistance associated with PZQ so alternative therapies are being a highly desirable goal.
The new trend of treatment is to use a natural plant extract as a safe and effective drug that provides promising results against schistosomias .one of these extracts is the
Genistein
In the present study, the effects of Genistein and PZQ and their combination as antishistosomal drugs was studied by means of the parasitological parameters, histopathological examinationa, scanning electron microscopy and measurement of interleukin 1β by ELISA test in serum samples.
The current experimental study was carried out on 100 albino which were divided into the following groups:
GroupI (non-infected mice): Comprising40 mice subclassified into 4 subgroups:
Subgroup (Ia): comprising 10 mice which non- infected and non- treated.
Subgroup (Ib): comprising 10 mice which non-infected and treated with Genistein.
Subgroup (Ic): comprising 10 mice which non -infected and treated with praziquantel.
Subgroup (Id): comprising 10 mice which non- infected and treated with Genistein and praziquantel.
group II (infected mice): Comprising 60 mice subclassified into 4 subgroups:
Subgroup (IIa): comprising 15 mice infected with Schistosoma mansoni without treatment (control positive).
Subgroup (IIb): Comprising 15 mice infected with Schistosoma mansoni and treated with Genistein only.
Subgroup (IIc): Comprising 15 mice infected with Schistosoma mansoni and treated with praziquantel only.
Subgroup (IId):Comprising15 mice infected with Schistosoma mansoni and treated with Genistein and praziquantel
The results of the present work showed
Genistein when given orally in a dose of 100mg/kg body weight in 4 divided doses, each 25mg/kg body weight/mouse over a period of 2 weeks; started 4wks post infection (p.i), caused significant reduction in total number of worms in S. mansoni infected mice (G II b) compared with the infected control untreated mice (P<0.001). The reduction percentage of male, female, couple and total worms were 30.43%, 25%, 41.41% and 33.58% respectively.
PZQ when given at a dose of 500 mg/kg for two successive days orally at 6 weeks post infection (p.i) caused pronounced curative effects on S. mansoni infected
Summary
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mice showing a significant reduction of male worms by 61.73%, female worms by 50.33%, couple worms by 82.18% and total worms by 79.64% as compared with the infected control group (P<0.001).