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العنوان
Assessment of Serum Level of InterLeukin 17 before and after Topical Application of Diphenylcyclopropenone in Alopecia Areata /
المؤلف
Abdallah, Omnia Mohammed.
هيئة الاعداد
باحث / أمنيه محمد عبدالله
مشرف / أمنيه محمد عبدالله
مشرف / علاء الدين سعد عبد الحميد
مشرف / رضوي السيد محمود
الموضوع
Dermatology.
تاريخ النشر
2019.
عدد الصفحات
74 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأمراض الجلدية
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة قناة السويس - كلية الطب - الأمراض الجلدية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Alopecia areata (AA) is a skin disease of unclear etiology although immunologic, genetic, and environmental factors may play an important role in the development of permanent or temporary hair loss. Foci of baldness are usually oval and may be of different sizes. The disease usually affects the scalp. In cases of AT, patients present total loss of hair on the scalp. In cases of AU, patients present the loss of hair over the entire scalp and body, including the scalp, armpits, groin, eyebrows and eyelashes. Clinically, the skin within the affected areas remains normal
IL-17 is an important cytokine not only for protective immunity against extracellular pathogens, but also for the clearance of intracellular pathogens. In addition to its important role in protective immunity, IL-17 plays a critical role in the pathogenesis of various autoimmune inflammatory diseases. IL-17-producing cells, including γδT cells, NK T cells, and innate lymphoid cells, are characterized by the expression of the transcription factor, retinoic acid receptor-related orphan receptor-γt. Dysregulation of protective immune responses causes autoimmune diseases.