الفهرس 
Four key factors involved in acne pathogenesisOnly 14 pages are availabe for public view
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Abstract
Background: Acne vulgaris is a disease of the pilosebaceous unit with
predominance at the face, neck, upper chest and back. Sebocytes were
identified as 1, 25 (OH) 2 D responsive target cells. This theory confirms
that vitamin D exerts an immune regulatory function in sebocytes, which
supports it's the anti-inflammatory effects in acne patients.
Objectives: To assess the role of vitamin D in treatment of acne vulgaris
and to study its relation to VDR Apa 1,Taq 1,Fok 1 and Cdx 2
polymorphisms.
Methods: This randomized control study included 300 acne patients. Group
1 received cholecalciferol 8,000 IU/day for three months. group 2 applied
1-2gm of topical vitamin D analogue for three months. group 3 had no
treatment. VDR gene Apa 1, Taq 1, Fok 1 & Cdx 2 polymorphisms were
examined by real time PCR with Taq Man allelic discrimination assay.
Serum 25(OH) D 3 was measured in all participants before and after
treatment by ELISA.
Results: Acne patients showed more significant decrease in serum 25(OH)
D 3 concentration (9.7ng/ml) than controls (26ng/ml). Systemic
cholecalciferol and topical vitamin D analogue had significantly decreased
GAGS by 21.88% & 38.75% respectively after treatment. Patients had
significant decrease in Taq 1 A-allele & AA genotype (47.5%, 10%) than
controls (80%, 60%) respectively.
Conclusion: vitamin D deficiency and VDR polymorphisms of Taq 1and
Apa 1 may increase the risk for AV. Systemic and topical vitamin D can be
used as a complementary therapy for AV.
Keywords: Acne vulgaris – vitamin D - VDR polymorphism.