الفهرس 
Anatomy of the CorneaOnly 14 pages are availabe for public view
 |  | from | 122 |  |  |
| | | from | 122 | | |
Abstract
Abstract
35 Purpose: The objective of this study is to compare the endothelial safety of
36 femtosecond laser (FSL) energy at two different dissection depths in
37 femtosecond laser-assisted deep anterior lamellar keratoplasty (FSDALK)
38 for keratoconus.
39 Methods: This prospective double-armed interventional study included 25
40 eyes from 21 patients with advanced keratoconus who underwent FSDALK
41 (big-bubble technique) at a trephination depth of 110 μm in group I (11
42 eyes) and 80 μm in group II (14 eyes)—all of which were anterior to the
43 Descemet’s membrane (DM). Visual acuity measurement, anterior and
44 posterior segment examination, corneal tomography, and specular
45 microscopy were performed preoperatively and at 3, 6, and 12 months,
46 postoperatively. Endothelial cell density, coefficient of variation, percentage
47 of cell hexagonality, and pachymetry were used to evaluate endothelial
48 safety.
49 Results: No statistically significant difference in any of the endothelial
50 safety parameters was found between the two groups. The mean 12-month
51 postoperative endothelial cell loss rate was 17.46% and 12.91% in group I
52 and II, respectively (P=0.345). Most of the endothelial cell loss occurred
4during the first three months after surgery. group II showed statistically
54 greater improvement in the mean keratometry values at all follow-up visits.
55 Conclusion: The endothelial safety profiles of lamellar FSL cuts at 110 μm
56 and 80 μm anterior to the DM are comparable. Cuts as deep as 80 μm
57 anterior to the DM can be safely applied without causing significant injury to
58 the endothelium. Further studies are needed to compare the endothelial
59 safety profiles of different FSL platforms available in the market