الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 238 |  |  |
| | | from | 238 | | |
Abstract
The aim of the investigation is to study the effect of stem cells versus
simvastatin on the mucous membrane and salivary glands of the tongue of rats with
streptozotocin-induced diabetes mellitus
Seventy five male albino rats with body weight ranging from 150-180gr.were
used in this investigation. They were divided into the following groups:-
Group1.1: consisted of 15 animals and served as controls.
group 2.1: consisted of 15 animals, they were subjected to a single intraperitoneal
injection of streptozotocin in a dose of 60mg/kg body weight for induction of
diabetes mellitus
group 3.1: consisted of 15 animals. They were subjected to induction of diabetes
mellitus in the same way as group 2.1 animals. One week later, the animals were
treated with simvastatin in a daily intraperitoneal dose of 5mg/kg body weight.
group 4: consisted of 30 rats that were subdivided as follows:
Subgroup.4.1: consisted of 15 animals subjected to induction of diabetes mellitus,
the same way as group 2.1 One week later they were subjected to single
intravenous infusion of mesenchymal bone marrow stem cells (1.5× 103 -106) cells
per rat in 0.2ml.phosphate buffer saline.
Subgroup. 4.2: consisted of 15 rats. They were used for isolation and culture of
bone marrow stem cells.