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العنوان
Feasibility of trans-esophageal echo in evaluating effect of remote ischemic preconditioning on left ventricular functions /
المؤلف
Eisa, Ahmed Amin Salama Mohammed.
هيئة الاعداد
باحث / أحمد أمين سلامه محمد عيسى
مشرف / مجدي ممدوح محمود عطاالله
مشرف / علاءالدين مازي عبده مازي
مشرف / حسام صلاح الدين العشماوي
مشرف / شرين علي السيد بكري
مناقش / نبيل عبدالرؤوف عبدالمجيد
مناقش / سهير مصطفى محمود
الموضوع
Surgical Intensive Care. Congenital heart disease.
تاريخ النشر
2021.
عدد الصفحات
114 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
التخدير و علاج الألم
تاريخ الإجازة
1/2/2021
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم التخدير والعنايه المركزه الجراحية
الفهرس
Only 14 pages are availabe for public view

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Abstract

This study was conducted on 56 patients scheduled for elective CABG. Patients were divided into RIPC group and control group with 28 patients in each group. Both laboratory and radiological works were reviewed in the preoperative period. The RIPC stimulus was 3 cycles of upper limb ischemia (5-min blood pressure cuff inflation to 200 mmHg and 5-min cuff deflation). The placebo stimulus was an identical cuff inflation cycle applied to a wooden cylinder acting as a dummy arm. Patients were monitored by pulse oximeter, capnogram, invasive arterial blood pressure, CVP and nasopharyngeal thermometer was positioned for continuous monitoring of core body temperature. Anesthesia was induced by propofol, fentanyl and atracurium in both groups and maintained by isoflurane with oxygen/ air mixture in the pre-and post-bypass time. Cardiopulmonary bypass machine was primed and heparin was given to facilitate going on bypass. Anesthesia was maintained using continuous infusion of propofol, fentanyl and atracurium. Patients were weaned from the bypass machine according to the department protocol. Hemodynamic parameters and CPB data were monitored. Left ventricular functions (EF, FS and FAC) are measured pre- and post- cardiopulmonary bypass. CRP was done immediately on arrival to ICU and was repeated at 24h and 48h postoperative. Also, RBG was done immediately on arrival to ICU and repeated every 6 hours in 1st 24 hour postoperative. Patient’s demographic data showed no significant difference between RIPC and control groups. Basal and intra-operative heart rate (beats /min) changes between the two groups showed no statistically significant differences. Also, Basal and intra-operative MAP (mmHg) changes between the two groups showed no statistically significant differences. As regard left ventricular function (EF, FS and FAC), there was no significant difference between the studied groups either pre- or post-cardiopulmonary bypass. Moreover, Anaesthesia time, cardiopulmonary bypass time and aortic cross clamp time showed no statistically differences between the studied groups. However, there was statistically significant difference between RIPC and control groups as regard postoperative levels of CRP which was significantly with lower levels in RIPC group than control group during patient arrival to ICU, 24 h, 48 h in ICU. Also, Basal, intraoperative and postoperative RBG show significant difference between RIPC and control groups at 240min and 300 min intraoperatively and postoperatively at 6 h lower levels in RIPC group than control group. In addition, the number of patients who needed vasoactive drugs and inotropes infusion and its type after weaning from cardiopulmonary bypass had no significant statistical difference between the studied groups.