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Abstract Preeclampsia is a leading cause of maternal mortality and morbidity worldwide. It is the most frequently encountered renal complication of pregnancy. Preeclampsia is a multisystem disorder commonly called as gestational hypertension with proteinuria or defective placental angiogenesis. Although the etiology of pre-eclampsia is not understood, the presence of a placenta is necessary and sufficient to cause the disorder. A fetus is not required because pre-eclampsia can occur with hydatidiform mole. A uterus is probably not required because pre-eclampsia may develop with abdominal pregnancy. Proposed mechanisms include impaired trophoblastic differentiation and invasion, immunologic response to pregnancy, and placental or endothelial abnormalities. Central to management is delivery, which removes the causative organ, namely the placenta. |