الفهرس 
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Abstract
Acne is a common chronic skin disease arising from the pilosebaceous unit, characterized by inflammatory, non‐inflammatory lesions, seborrhoea and/or various degrees of scarring. Recent research has revealed that circRNAs can regulate alternative splicing and transcription, and modulate the parental gene expression by acting as a miRNA sponge in various diseases. To date, the expression profile and the regulatory relationship of circRNAs in acne, especially severe acne, are still unknown.
Circular RNA (circRNA) has been classified as noncoding RNA with a covalent closed continuous loop, the 3′and 5′ ends of which are normally joined together to increase its own stability. More recently, circRNA has been shown to encode proteins and may be involved in the regulation of gene transcription. This provides more evidence for the involvement of circRNA in disease progression. Accumulating investigations have found that the expression of many circRNAs is abnormal in plenty of skin diseases such as malignant melanoma, psoriasis, and abnormal wound healing.
CircRNAs are a type of RNA characterized with covalently closed continuous loop, which has been detected in viruses, plant and animals. More and more researches have focused on the potential functions of circRNAs that as miRNA sponges in parental gene expression regulation to influence physiologic processes as well as disease. More recently, a small number of miRNAs such as miR‐143 and miR‐338‐3p have been firstly demonstrated as a major player in the regulation of inflammatory responses in acne.
Acne is a common chronic skin disease with a multifactorial etiology and pathogenesis. Recently, circular RNAs (circRNAs) have been identified as a key factor in regulating gene expression through circRNA-miRNA-mRNA networks in many biological processes and human diseases. However, the circRNAs expression in patients with acne is still unknown.
Many circRNAs are abnormally expressed in skin disorders, and they are involved in the occurrence and development of skin diseases through a variety of molecular mechanisms, which provide more evidence for circRNAs as biomarkers for diagnosis, prognosis, and therapy of skin diseases.
The main purpose of the study was to evaluate Circular RNA Expression in Patient with Acne and to correlate its level with acne severity.
This was a case control study was conducted at conducted at Dermatology outpatient cinic at Beni-Suef University hospital including 40 with acne vulgaris and 40 normal as control. The duration of the study ranged from 6-12 months.
The main results of the study revealed that:
According to age among the cases group the mean age 23.20(±4.9 SD) and range (18-32) and among the control group the mean age more than 30 with mean age 23.5 (±4.3 SD) and range (18-35). There was no statistically significant difference between the studied groups as regard age.
According to gender among the cases group 22.5% of them were males and 77.5% were females and among the control group 15% were males and 85% were females There was no statistically significant difference between the studied groups as regard gender
According to severity there were 11 (27.5%) with Mild acne, 14 (35%) with Moderate acne, and 15 (37.5%) with Severe acne. The mean Disease duration was 2.06(±2.1 SD) with range (0.1 -8) years.
The mean Circ RNA 0001073 for cases group was 0.47 (±0.3 SD) with range (0.11-1.20) and that the mean CIRCULAR RNA 0001073 for control group was 1.03 (±0.1 SD) with range (0.95-1.20). There was high statistically significant difference between the studied groups as regard CIRCULAR RNA 0001073.
There is high significant relation between severity of acne and circular RNA 0001073.
There is significant moderate negative linear correlation between Circ RNA 0001073 expression in blood samples and disease duration in studied Acne Vagaries patients.
There is high significant negative correlation between Circ RNA 0001073 and disease severity and significant moderate negative linear correlation between Circ RNA 0001073 and disease duration while there is no significant correlation between RNA 0001073 and age or sex.
Based on our findings, we recommend for further studies on larger sample size and on large geographical scale to emphasize our conclusion.