الفهرس 
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Abstract
In patients with temporal lobe epilepsy (TLE) significant cognitive deficits frequently develop especially in the domains of memory, verbal fluency, and visuospatial.
Several factors may adversely affect cognition including the underlying pathology, the effects of the epilepsy itself, and the impact of recurrent seizures. In addition, antiepileptic drugs (AEDs) can affect memory by reducing the efficiency of coding and retrieval processes via changes in concentration and cognitive processing.
Apo E has emerged. However, its role in TLE has not been fully elucidated. The current study was designed to estimate serum levels of APO E in patients suffering from TLE compared to healthy control subjects, and investigate the possible correlation between serum levels of APO E with cognitive functions in TLE patients.
The study was conducted on 80 subjects, 40 patients with TLE and 40 healthy control subjects, all were sex and age matched. Patients and volunteers underwent a complete clinical assessment, interictal EEG and MRI of the brain. Evaluation of cognitive domains was done using MMSE and ACE-R. Serum Apo E levels were measured for them. Data were then collected and statistically analyzed.
Results of the current study can be summarized as follows:
(1) There was a highly significant increase of serum Apo E level in the patients group compared to healthy control subjects
(2) The mean scores of MMSE was significantly less in TLE patients compared to the control subjects.
(3) The mean values of the total scores, memory and visuospatial scores of ACE-R were significantly lower in TLE patients when compared to the control group.
(4) Serum Apo E levels were significantly negatively correlated with total score of MMSE, ACE-R, memory, and visuospatial ability (subsets of ACE-R).
(5) Serum Apo E was non significantly positively correlated with age.
(6) Apo E was significantly positively correlated with age of onset, and disease duration of TLE.
(7) Significant correlation was found between Apo E and ACE-R with EEG.