الفهرس 
Post-operative painOnly 14 pages are availabe for public view
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Abstract
Hemorrhoid disease is a common disorder. Anal canal has rich innervation , so postoperative pain is still the most significant problem. Traditional analgesia in the post-operative period is based on opioids, non-steroidal anti-inflammatory drugs (NSAIDs) which can result in higher incidence of complications. Hence, the search for an ideal drug continues. Pregabalin is a structural analogue of the inhibitory neurotransmitter ϒ - aminobutyric acid. It binds to the α- -δ subunit of voltage-gated calcium channels, reducing the release of several excitatory neurotransmitters and blocking the development of hyperalgesia and central sensitization. Pregabalin has anticonvulsant, anti-hyperalgesic, and anxiolytic properties. Our study was performed to evaluate the effect of pregabalin on postoperative analgesia after anal surgeries under spinal anesthesia. This study was approved by the Ethics Committee and was carried on sixty patients ASA І & ІІ, aged between and years, admitted to Tanta University Hospital and scheduled for elective anal surgeries. Exclusion criteria were Patient refusal, contraindications to spinal anesthesia as coagulopathy, known allergy to pregabalin, if patients had used opioid or non-opioid analgesics within the previous hours, positive history of pregabalin consumption, psychiatric disorders, history of seizures, known liver or renal diseases and chronic pain syndromes. Patients were divided into equal groups: group I (control group) received a placebo capsule / h starting at the day before surgery and for hrs postoperative , while group II (pregabalin group) received a pregabalin mg capsule / h starting at the day before surgery and for hrs postoperative. Pethidine mg was given as rescue analgesia if pain VAS ≥ . After the operation heart rate, mean arterial pressure, postoperative pain (using point Visual Analogue Scale (VAS), Ramsay Sedation Score (RSS), time to first request of rescue analgesia, total hours pethidine consumption and postoperative complications were measured in the groups immediately after recovery, ndhr, thhr, thhr, thhr, thhr, thhr, thhr and ndhr postoperative. In our study we found that the mean value of heart rate of group II (Pregabalin group) was significantly lower than that of group I (Control group) at th& thhr and without significant difference at , nd, th, th, th, th, th, nd hr postoperative. The mean values of VAS score in group II (Pregabalin group) was significantly lower than that of group I (control group) at th, th, th & th hr postoperative. But there were insignificant changes in VAS score at nd, th, th, th& nd hr postoperative. We also found that mean value of time to first request of rescue analgesia was significantly longer in group II (Pregabalin group) than in group I (Control group). The mean value of total pethidine consumption was significantly lower in group II (Pregabalin group) than in group I (Control group).