الفهرس 
Aim of the Work.Only 14 pages are availabe for public view
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Abstract
BACKGROUND: Acne vulgaris is a multifactorial disease
affects the pilosebaceous follicle and results in inflammatory
and non-inflammatory lesions with certain role of cytokines in
its pathogenesis. Interleukin-35 cytokine has been shown to
exhibit immunosuppressive activities which are distinct from
other members of IL-12 family. IL-35 is also unique in that it is
expressed primarily by regulatory T- cells (Tregs) rather than
by antigen-presenting cells (APCs).
OBJECTIVE: To investigate the role of IL-35 in the
pathogenesis of acne vulgaris by assessing its levels in
lesional skin and serum of patients with acne vulgaris
compared with normal individuals.
METHODS: 44 subjects were divided into 2 groups: group 1:
It included measurement of serum and tissue level of
interleukin 35 in 22 acne vulgaris patients with age group (15-
30). All of them were subjected to detailed history taking,
dermatological and general examination. Group2: It included
22 healthy, age, and gender matched individuals as a control
group.
RESULT: Our results show a highly statistically significant positive
correlation between acne patient and control regarding IL-35 level
in serum and tissue.
CONCLUSION: Our study may provide evidence that Serum
and Tissue IL-35 are important anti-inflammatory cytokines.
They are actively expressed by the sebaceous glands. They
have significant higher expression in acne patients. They are
hypothesized to play a key role in acne cure at multiple points,
through their anti-inflammatory action. This effect may be
hindered in acne vulgaris by undiscovered obstacles.
KEY WORDS: Acne vulgaris and cytokines, IL-35 anti-
inflammatory cytokine.