الفهرس 
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Abstract
Summary
Beta thalassemia is one of the commonest inherited single gene disorders. In β- thalassemia there is no or decreased production of β globin chain, theα- chain formation will continue to occur. This elevated biosynthesis of α- chain makes the developing RBCs more fragile resulting in early destruction, ineffective erythropoeisis and anemia.
Selenium (Se) is a crucial trace element for proper health and development of human as well as other mammals. This micronutrient is best known for its peculiar biological roles in redox balance and might be considered a promising chemopreventive factor against many tumors. It plays a role in anti -inflammatory and antiviral activities, prevention heart diseases, and in delaying the progression of neurodegenerative diseases as well as AIDS.
Another important trace element present in the body is Mn. It participates in a lot of enzymatic reactions. This element acts as an essential component of various metalloenzymes and as an activator for some metal-enzyme complexes.
This study aimed to assess Se and Mn serum levels in 100 children divided into 2 groups, group I included 50 pediatric patients with thalassemia who were already diagnosed and were attending the pediatric Haematology Clinic in Beni suef University Hospital And group II included 50 healthy children.
There were no significant differences between patients and controls as regarding age and gender.
Weight in patients was significantly lower than in controls with mean (32.5800± 12.70078) (55.9600 ± 28.45545) respectively, with p value of (0.001).
Height in patients was significantly lower than in controls with mean (26.0000± 14.58263) (62.7000± 22.88414) respectively, with p value of (0.001).
Serum Mn was significantly higher in cases than in control with mean (99.8600± 8.31524) (34.5200± 35.11104) respectively with p value (0.000 ) .
Serum Se showed insignificant difference between patients and controls with mean (45.9800± 37.73403) (34.5200± 35.11104) respectively with P value (0.119).