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Abstract Keratoconus is the most common primary corneal disease. It is a bilateral ectatic corneal degeneration characterized by localized corneal thinning which leads to protrusion of the thinned cornea. Detecting early keratoconus patients has a major clinical significance in the field of refractive surgery to decrease the incidence of post-Lasik complications. Previous studies showed that Higher order aberrations (HOAs) were higher in KC in comparison to normal eyes. Our aim of work is to compare high order aberrations (HOAs ) between keratoconus (KC), Keratoconus Suspects (KCS) and normal eyes. We have found that both RMS of Total aberrations and RMS of HOAs differs significantly between keratoconus suspect eyes and normal eyes. Our study demonstrates that in keratoconus cases, sometimes one of the eyes does not exhibit the clinical and topographical findings to diagnose keratoconus, whereas, it may be in a subclinical phase with different values compared to the eyes of normal people, particularly with regard to surface regularity indices, elevation values, and corneal HOAs. Therefore, we believe that a comprehensive approach that includes: the corneal curvature map, elevation map, and corneal HOAs, should be evaluated collectively when diagnosing subclinical keratoconus and selecting eligible patients prior to refractive surgery. Also, this early detection may aid in early management decisions of the disease (by methods such as collagen cross-linking) and thus improve quality of life by virtue of delaying (if not eliminating) the need for subsequent corneal transplantation. We recommend that further studies should investigate more charachteristic features between KCS and normal eyes using different diagnostic corneal indices in order to improve early KC detection and to decrease post-LASIK complications. |