الفهرس 
ANATOMY OF KNEE JOINTOnly 14 pages are availabe for public view
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Abstract
Introduction: Osteoarthritis is the most common chronic
degenerative joint disease for which there is no cure. It is
characterized by degeneration of all joint tissues, mainly articular
cartilage and subchondral bone. Among the joints, knees are the
most affected by OA, thus causing severe disability. N-Acetyl
phenylalanine glucosamine (NAPA) is a derivative of glucosamine
(GlcN), which is a constituent of the glycosaminoglycans (GAGs) of
cartilage extracellular matrix.
Aim of the work: This work was performed to study the possible
curative effect of N-acetyl phenylalanine glucosamine on surgically
induced Osteoarthritis in knee joint of adult male albino rat.
Materials and Methods: This study was performed on 28 male
adult albino rats. They were divided into three groups: group I
included eight animals that were divided into two subgroups, IA
(control) & IB (underwent Sham operation), group II included ten
animals underwent DMM surgery without receiving any subsequent
treatment, group III included ten animals underwent DMM surgery
then received single intraarticular injection of NAPA after 4 weeks
from the surgery, they were divided into two equal subgroups IIIA
(sacrificed after 2 weeks) and IIIB (sacrificed after 4 weeks) At the
end of the experiment, knee joints of all the animals were obtained
and processed for histological and immunohistochemical studies.
Results: Hematoxylin and Eosin stained sections showed moderate
degree of OA in group II that was improved in the group III.
Mallory trichrome stained sections revealed decreased collagen
content in group II that was also improved in group III. The same
results were found as regards the GAGs content of the cartilage matrix that was clearly decreased in group II and restored in group
III.
Conclusion: from the present study it could be concluded that the
osteoarthritic changes induced by surgical DMM in adult male
albino rats can be improved by subsequent intra-articular
administration of NAPA.