الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Resistin is a novel polypeptide derived from adipocytes in rodents. Many studies on human, mice, porcine, yak, goat and sheep revealed and reviewed that resistin incriminated in many diseases such as insulin resistance, obesity, type2 diabetes mellitus, CVD, atherosclerosis, endothelial dysfunction, hypertension, thrombosis, angiogenesis defects, smooth muscle cell dysfunction, tumorigenesis, rheumatic diseases and inflammation throughout the body. Although some conclusions on presence of resistin which have been derived from rodents, humans, cattle, buffalo, sheep, pig, hamster, but up till now, studies analyzing the expression and distribution of resistin mRNA in camelus dromadrius are lacking. In addition, the presence of resistin protein in blood and tissues has not been detected in camels. So the present study was performed to detect resistin protein in blood, tissues of Arabian camels and to examine the expression and distribution pattern of resistin gene, on the mRNA level, in camel various muscle types and adipose tissue by using different molecular biological techniques. Real-time PCR analysis showed the expression levels of resistin mRNA, in the camel various tissues. This technique showed high levels in adipose tissue especially visceral and epididymal fat in comparison to other tissues as hump, different muscle types. Using ELISA technique, the present study could identify and quantify resistin protein in camel circulation, muscles and adipose tissue homogenates. The profiles of resistin mRNAs were consistently matched with the profiles of resistin protein The resistin protein and mRNA were highest in adipose tissue especially visceral and epididymal fat than that in other tissues of Arabian camels. The previous data suggest that resistin may has beneficial physiological role(s) in glucose homeostasis and lipid metabolism in Arabian camels. Also, resistin might be involved in the regulation of cardiac physiology in Arabian camels. Collectively, these new finding extend the knowledge on resistin. Therefore, further studies should be performed to predict its roles, mechanisms of action and pathways under several regulators in camel species.